Description
Retatrutide is a triple agonist that targets the receptors of 3 hormones, mimicking their effects to improve blood sugar levels and promote weight loss. The 3 hormones are:
Glucagon-like peptide-1 (GLP-1)
Slows down digestion and how long it takes for food to pass through the stomach, suppresses your appetite, and stimulates insulin production to manage blood sugar levels.
Glucose-dependent insulinotropic polypeptide (GIP)
Increases the amount of insulin the pancreas releases to regulate blood glucose (sugar) levels and lowers food intake.
Glucagon
A naturally occurring hormone in the body that controls blood sugar levels and helps break down fat more effectively into fatty acids, which can be used for energy instead of being stored.
By mimicking the effects of these hormones, retatrutide helps you lose weight by suppressing your appetite, slowing digestion, and helping your body break down fat more effectively. Because of this, retatrutide is thought to be more effective than Wegovy, which only binds to GLP-1 receptors, and Mounjaro, which is a dual agonist that mimics the effects of GLP-1 and GIP.
Clinical trials and results
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Retatrutide is currently in phase 3 clinical trials for weight loss, but results from phase 2 trials are promising. At the highest weekly 12mg dose, participants lost an average of 24.2% of their starting body weight over 48 weeks. Within this group, 26% of people also lost at least 30% of their initial body weight.
A lower 4mg weekly dose also resulted in impressive weight loss results, with an average loss of 17% over 48 weeks and:
- 92% of participants lost at least 5% of their starting body weight
- 75% lost at least 10% of their body weight
- 60% lost at least 15% of their starting weigh
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